Dataset Information
Base-Mediated Meerwein-Ponndorf-Verley Reduction of Aromatic and Heterocyclic Ketones.
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ABSTRACT:
SUBMITTER: Boit TB
PROVIDER: S-EPMC7193670 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Base-Mediated Meerwein-Ponndorf-Verley Reduction of Aromatic and Heterocyclic Ketones.
Organic letters 20190722 16
An experimental protocol to achieve the Meerwein-Ponndorf-Verley (MPV) reduction of ketones under mildly basic conditions is reported. The transformation is tolerant of a range of ketone substrates, including <i>O</i>- and <i>S</i>-containing heterocycles, is scalable, and shows potential to be used as a platform to access enantioenriched products. These studies provide a general method for achieving the reduction of ketones under mildly basic conditions and offer an alternative protocol to more ...[more]