Ontology highlight
ABSTRACT:
SUBMITTER: Fong JY
PROVIDER: S-EPMC7194031 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Fong Jia Yi JY Pignata Luca L Goy Pierre-Alexis PA Kawabata Kimihito Cojin KC Lee Stanley Chun-Wei SC Koh Cheryl M CM Musiani Daniele D Massignani Enrico E Kotini Andriana G AG Penson Alex A Wun Cheng Mun CM Shen Yudao Y Schwarz Megan M Low Diana Hp DH Rialdi Alexander A Ki Michelle M Wollmann Heike H Mzoughi Slim S Gay Florence F Thompson Christine C Hart Timothy T Barbash Olena O Luciani Genna M GM Szewczyk Magdalena M MM Wouters Bas J BJ Delwel Ruud R Papapetrou Eirini P EP Barsyte-Lovejoy Dalia D Arrowsmith Cheryl H CH Minden Mark D MD Jin Jian J Melnick Ari A Bonaldi Tiziana T Abdel-Wahab Omar O Guccione Ernesto E
Cancer cell 20190801 2
Cancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur in leukemias, as well as in a variety of solid tumors, and confer dependence on wild-type splicing. These observations have led to clinical efforts to directly inhibit the spliceosome in patients with refractory leukemias. Here, we identify that inhibiting symmetric or asymmetric dimethylation of arginine, mediated by PRMT5 and type I protein arginine methyltransferases (PRMTs), respectively, reduces splicing ...[more]