Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC7194358 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Kim Jihye J Alejandro Brian B Hetman Michal M Hattab Eyas M EM Joiner Joshua J Schroten Horst H Ishikawa Hiroshi H Chung Dong-Hoon DH
PLoS pathogens 20200501 5
Zika virus (ZIKV) can infect and cause microcephaly and Zika-associated neurological complications in the developing fetal and adult brains. In terms of pathogenesis, a critical question is how ZIKV overcomes the barriers separating the brain from the circulation and gains access to the central nervous system (CNS). Despite the importance of ZIKV pathogenesis, the route ZIKV utilizes to cross CNS barriers remains unclear. Here we show that in mouse models, ZIKV-infected cells initially appeared ...[more]