Ontology highlight
ABSTRACT:
SUBMITTER: Gutierrez E
PROVIDER: S-EPMC7195048 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Gutierrez Esteban E Lütjohann Dieter D Kerksiek Anja A Fabiano Marietta M Oikawa Naoto N Kuerschner Lars L Thiele Christoph C Walter Jochen J
Life science alliance 20200430 6
Presenilins (PS) are the catalytic components of γ-secretase complexes that mediate intramembrane proteolysis. Mutations in the PS genes are a major cause of familial early-onset Alzheimer disease and affect the cleavage of the amyloid precursor protein, thereby altering the production of the amyloid β-peptide. However, multiple additional protein substrates have been identified, suggesting pleiotropic functions of γ-secretase. Here, we demonstrate that inhibition of γ-secretase causes dysregula ...[more]