Ontology highlight
ABSTRACT:
SUBMITTER: Eshraghi M
PROVIDER: S-EPMC7195186 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Eshraghi Mehdi M Ramírez-Jarquín Uri Nimrod UN Shahani Neelam N Nuzzo Tommaso T De Rosa Arianna A Swarnkar Supriya S Galli Nicole N Rivera Oscar O Tsaprailis George G Scharager-Tapia Catherina C Crynen Gogce G Li Qin Q Thiolat Marie-Laure ML Bezard Erwan E Usiello Alessandro A Subramaniam Srinivasa S
Science advances 20200501 18
The therapeutic effects of l-3,4-dihydroxyphenylalanine (l-DOPA) in patients with Parkinson's disease (PD) severely diminishes with the onset of abnormal involuntary movement, l-DOPA-induced dyskinesia (LID). However, the molecular mechanisms that promote LID remain unclear. Here, we demonstrated that RasGRP1 [(guanine nucleotide exchange factor (GEF)] controls the development of LID. l-DOPA treatment rapidly up-regulated RasGRP1 in the striatum of mouse and macaque model of PD. The lack of RasG ...[more]