Ontology highlight
ABSTRACT:
SUBMITTER: Kovalev K
PROVIDER: S-EPMC7195465 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200501 1
The light-driven sodium-pumping rhodopsin KR2 from Krokinobacter eikastus is the only non-proton cation active transporter with demonstrated potential for optogenetics. However, the existing structural data on KR2 correspond exclusively to its ground state, and show no sodium inside the protein, which hampers the understanding of sodium-pumping mechanism. Here we present crystal structure of the O-intermediate of the physiologically relevant pentameric form of KR2 at the resolution of 2.1 Å, rev ...[more]