Ontology highlight
ABSTRACT:
SUBMITTER: Cubillos-Zapata C
PROVIDER: S-EPMC7195702 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Cubillos-Zapata Carolina C Angulo Iván I Almanza Horacio H Borrego Belén B Zamora-Ceballos María M Castón José R JR Mena Ignacio I Blanco Esther E Bárcena Juan J
Veterinary research 20200501 1
We report the generation, characterization and epitope mapping of a panel of 26 monoclonal antibodies (MAbs) against the VP1 capsid protein of feline calicivirus (FCV). Two close but distinct linear epitopes were identified at the capsid outermost surface (P2 subdomain) of VP1, within the E5'HVR antigenic hypervariable region: one spanning amino acids 431-435 (PAGDY), highly conserved and recognized by non-neutralizing MAbs; and a second epitope spanning amino acids 445-451 (ITTANQY), highly var ...[more]