Ontology highlight
ABSTRACT:
SUBMITTER: Blockhuys S
PROVIDER: S-EPMC7196078 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Blockhuys Stéphanie S Brady Donita C DC Wittung-Stafshede Pernilla P
Breast cancer (Tokyo, Japan) 20200102 3
Copper is involved in different hallmarks of cancer, including metastasis, but responsible copper-binding proteins and pathways are not clear. The copper chaperone ATOX1 was recently shown to play a role in breast cancer cell migration, which is a key step in metastasis. Since most cancer-related deaths are due to metastasis, we hypothesized that ATOX1 mRNA expression may be associated with breast cancer disease progression and thus, a prognostic biomarker in breast cancer. We therefore studied ...[more]