Ontology highlight
ABSTRACT:
SUBMITTER: Manas A
PROVIDER: S-EPMC7196324 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Mañas Adriana A Davis Aislinn A Lamerand Sydney S Xiang Jialing J
Histochemistry and cell biology 20180417 1
Bax∆2 is a pro-apoptotic protein originally discovered in colon cancer patients with high microsatellite instability. Unlike most pro-apoptotic Bax family members, Bax∆2 mediates cell death through a non-mitochondrial caspase 8-dependent pathway. In the scope of analyzing the distribution of Bax∆2 expression in human tissues, we examined a panel of human brain samples. Here, we report four cerebellar cases in which the subjects had no neurological disorder or disease documented. We found Bax∆2 p ...[more]