Dataset Information

The role of carotid stenosis ultrasound scale in the prediction of ischemic stroke.

ABSTRACT:

Introduction

To improve the accuracy of ultrasound techniques for the assessment of carotid stenosis, we designed a novel carotid artery stenosis ultrasound scale (CASUS), and evaluated its accuracy, reliability, and its value in predicting the occurrence of cardiovascular and cerebrovascular diseases in a prospective study.

Methods

A total of 750 patients with first-time ischemic stroke and hospitalized within 24 h were enrolled in the study. Using color Doppler ultrasound (CDUS), the degree of stenosis and blood flow (BF) in bilateral internal carotid arteries (ICA) and the V1-V3 segment of vertebral arteries (VA) was assessed. Cubic simulation curves for BF and global blood flow (GBF) over the stenosis score (SS), total stenosis score (TSS), and radiological imaging- total stenosis score (RI-TSS) were fitted and compared. The receiver operating characteristic (ROC) curves using TSS, RI-TSS, or GBF to predict various ischemic stroke endpoints were also analyzed and compared.

Results

There was a linear relationship between SS and BF both ICA and VA (R2 were 0.734 and 0.783, respectively, both P < 0.05). Both TSS and RI-TSS with GBF showed an inverse "S" curve relationship (R2 was 0.839 and 0.843, all P < 0.05). The AUC values of TSS-based and RI-TSS-based predictions of each endpoint were all greater than 0.7 (all P < 0.05), but the differences of the AUC values between TSS, RI-TSS, and GBF were not statistically significant (all P > 0.05).

Conclusions

The novel CASUS can better reflect the level of cerebral reperfusion in patients with ischemic stroke and can better predict the occurrence of cardiovascular and cerebrovascular diseases.

SUBMITTER: Tang Y

PROVIDER: S-EPMC7196942 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Publications

The role of carotid stenosis ultrasound scale in the prediction of ischemic stroke.

Tang Yi Y Wang Ming-Yu MY Wu Tao-Tao TT Zhang Jian-Yu JY Yang Ru R Zhang Bo B Shi Ying Y Meng Pin P Ji Niu N Sun Yongan Y Xu Ying-da YD Xu Bing-Chao BC Zhou Xin-Yu XY He Xiao-Bing XB Zhang Guang-Hui GH Niu Xiao-Qin XQ Li Zai-Po ZP Wang Bei B Xu Bei B Cai Zeng-Lin ZL Zhang Yong-Jin YJ He Ming-Li ML

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20200103 5

<h4>Introduction</h4>To improve the accuracy of ultrasound techniques for the assessment of carotid stenosis, we designed a novel carotid artery stenosis ultrasound scale (CASUS), and evaluated its accuracy, reliability, and its value in predicting the occurrence of cardiovascular and cerebrovascular diseases in a prospective study.<h4>Methods</h4>A total of 750 patients with first-time ischemic stroke and hospitalized within 24 h were enrolled in the study. Using color Doppler ultrasound (CDUS) ...[more]

PMID: 31901124

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Project description:PurposeWe aimed to analyze retinal neurovascular unit (RNVU) alterations and function via optical coherence tomography angiography (OCTA) and full-field electroretinography (ERG) in patients with ischemic stroke (IS).MethodsOCTA was used to measure RNVU changes in 229 participants (101 with IS and 128 healthy controls). The RETeval device was used to record full-field electroretinograms (FERGs) in 40 participants (14 with IS and 26 healthy controls). Logistic regression models for IS were constructed. Receiver operating characteristic (ROS) curves were constructed to assess the predictive value of various models for IS.ResultsPatients with ipsilateral internal carotid artery stenosis (ICAS) had a greater occurrence of IS. A decrease in the vascular density (VD) of the parafovea, FD-300, and nasal optic disc; a decrease in the thickness of the retinal nerve fiber layer (RNFL) around the nasal optic disc; and an increase in the acircularity index (AI) were observed in patients with IS (P < 0.05). An increase in the AI was identified as a risk factor for IS, whereas the other factors were found to be protective factors. The IS group presented a delayed a-wave implicit time and decreased b-wave amplitudes at the scotopic point. By incorporating traditional risk factors, the degree of ipsilateral ICAS, and OCTA parameters, a high predictive value for IS was achieved (area under the curve [AUC] = 0.933).ConclusionsPatients with IS without visible fundus lesions presented changes in the RNVU, characterized by reductions in retinal VD and RNFL thickness, alongside dysfunction of photoreceptor cells and bipolar cells. The combination of RNVU changes with traditional risk factors can enhance the prediction of IS, which provides valuable guidance for monitoring this disease.Translational relevanceThis study demonstrated that the combination of OCTA parameters, the degree of ipsilateral ICAS, and traditional risk factors could can enhance the prediction of IS. These findings provide valuable guidance for monitoring IS by assessing RNVUs.

Dataset Information

The role of carotid stenosis ultrasound scale in the prediction of ischemic stroke.

Introduction

Methods

Results

Conclusions

Publications

The role of carotid stenosis ultrasound scale in the prediction of ischemic stroke.

Similar Datasets

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