Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Gu S
PROVIDER: S-EPMC7197135 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Elevated <i>TNFRSF4</i> gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia.
Gu Siyu S Zi Jie J Han Qi Q Song Chunhua C Ge Zheng Z
Cancer cell international 20200504
<h4>Background</h4>We used bioinformatic tools to dichotomize 157 non-M3 AML patients from the TCGA dataset based on the presence or absence of <i>TP53</i> mutations, and screened out a key gene related to <i>TP53</i> mutation for future analysis.<h4>Methods</h4>DEGs were analyzed by R package "DESeq2" and then run GSEA, GO enrichment, KEGG pathway and PPI network. Hub genes were selected out according to MCC. Log-rank (Mantel-Cox) test was used for survival analysis. Mann-Whitney U's nonparamet ...[more]
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