Targeted chemotherapy overcomes drug resistance in melanoma.
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ABSTRACT:
SUBMITTER: Yue J
PROVIDER: S-EPMC7197350 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Targeted chemotherapy overcomes drug resistance in melanoma.
Yue Jingyin J Vendramin Roberto R Liu Fan F Lopez Omar O Valencia Monica G MG Gomes Dos Santos Helena H Gaidosh Gabriel G Beckedorff Felipe F Blumenthal Ezra E Speroni Lucia L Nimer Stephen D SD Marine Jean-Christophe JC Shiekhattar Ramin R
Genes & development 20200402 9-10
The emergence of drug resistance is a major obstacle for the success of targeted therapy in melanoma. Additionally, conventional chemotherapy has not been effective as drug-resistant cells escape lethal DNA damage effects by inducing growth arrest commonly referred to as cellular dormancy. We present a therapeutic strategy termed "targeted chemotherapy" by depleting protein phosphatase 2A (PP2A) or its inhibition using a small molecule inhibitor (1,10-phenanthroline-5,6-dione [phendione]) in dru ...[more]
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