Ontology highlight
ABSTRACT:
SUBMITTER: Verma AK
PROVIDER: S-EPMC7197448 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Verma Alexander K AK Messerli Shanta M SM Miskimins W Keith WK
Oncotarget 20200428 17
Intratumoral lactate production negatively correlates with survival and tumor clearance in the setting of human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC). Robust anti-tumor immune activity is required for tumor clearance in human patients and animal models of this disease, and intratumoral lactate interferes with this process. While lactate is known to directly inhibit T cell activity, recent evidence has demonstrated that lactate can affect gene expressi ...[more]