Ontology highlight
ABSTRACT:
SUBMITTER: Hu H
PROVIDER: S-EPMC7197765 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Hu Huayou H Chen Si-Jie SJ Mandal Mukunda M Pratik Saied Md SM Buss Joshua A JA Krska Shane W SW Cramer Christopher J CJ Stahl Shannon S SS
Nature catalysis 20200224 4
Cross-coupling reactions enable rapid, convergent synthesis of diverse molecules and provide the foundation for modern chemical synthesis. The most widely used methods employ sp<sup>2</sup>-hybridized coupling partners, such as aryl halides or related pre-functionalized substrates. Here, we demonstrate copper-catalysed oxidative cross coupling of benzylic C-H bonds with alcohols to afford benzyl ethers, enabled by a redox-buffering strategy that maintains the activity of the copper catalyst thro ...[more]