Ontology highlight
ABSTRACT:
SUBMITTER: Santos LRD
PROVIDER: S-EPMC7198034 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Santos Lígia Ramos Dos LRD Almeida Jucimara Ferreira Figueiredo JFF Pimassoni Lúcia Helena Sagrillo LHS Morelato Renato Lírio RL Paula Flavia de F
Genetics and molecular biology 20200316 1
Genome-wide associations studies (GWAS) are detecting new variants associated with late-onset of Alzheimer's disease (LOAD), a multifactorial neurodegenerative disorder. The variants rs744373 BIN1, rs11136000 CLU and rs3764650 ABCA7 uncovered by GWAS led to different AD pathways, such as metabolism, trafficking and endocytosis of lipids and inflammation. However, most of the association studies did not replicate these variants with significance. This could be due to a small power effect evident ...[more]