Ontology highlight
ABSTRACT:
SUBMITTER: Van Weehaeghe D
PROVIDER: S-EPMC7198372 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20190927 4
Neuroinflammation is important in amyotrophic lateral sclerosis (ALS). The P2X7 receptor (P2X7R) is a promising target for neuroinflammation. The objective of this study was to compare <sup>18</sup>F-DPA714, a second-generation translocator protein tracer, with <sup>11</sup>C-JNJ717, a novel P2X7R tracer, in vitro and in vivo in ALS. <b>Methods:</b> For the in vitro portion of the study, autoradiography with <sup>18</sup>F-DPA714 and <sup>11</sup>C-JNJ717 was performed on human ALS brain section ...[more]