Ontology highlight
ABSTRACT:
SUBMITTER: Buhler S
PROVIDER: S-EPMC7198472 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Buhler Stéphane S Baldomero Helen H Ferrari-Lacraz Sylvie S Nunes José Manuel JM Sanchez-Mazas Alicia A Massouridi-Levrat Stravroula S Heim Dominik D Halter Jörg J Nair Gayathri G Chalandon Yves Y Schanz Urs U Güngör Tayfun T Nicoloso Grazia G Tiercy Jean-Marie JM Passweg Jakob J Villard Jean J
Bone marrow transplantation 20190405 10
HLA matching is a critical factor for successful allogeneic hematopoietic stem cell transplantation. For unrelated donor searches, matching is usually based on high-resolution typing at five HLA loci, looking for a 10/10 match. Some studies have proposed that further matching at the haplotype level could be beneficial for clinical outcome. In this study, we determined the phased haplotypes of 291 patients using family members and segregation analysis. The sum of ranks of the haplotypes carried b ...[more]