Ontology highlight
ABSTRACT:
SUBMITTER: Oizel K
PROVIDER: S-EPMC7198490 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Oizel Kristell K Tait-Mulder Jacqueline J Fernandez-de-Cossio-Diaz Jorge J Pietzke Matthias M Brunton Holly H Lilla Sergio S Dhayade Sandeep S Athineos Dimitri D Blanco Giovanny Rodriguez GR Sumpton David D Mackay Gillian M GM Blyth Karen K Zanivan Sara R SR Meiser Johannes J Vazquez Alexei A
Cell death & disease 20200504 5
Formate is a precursor for the de novo synthesis of purine and deoxythymidine nucleotides. Formate also interacts with energy metabolism by promoting the synthesis of adenine nucleotides. Here we use theoretical modelling together with metabolomics analysis to investigate the link between formate, nucleotide and energy metabolism. We uncover that endogenous or exogenous formate induces a metabolic switch from low to high adenine nucleotide levels, increasing the rate of glycolysis and repressing ...[more]