Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC7198603 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200504 1
Signal amplification in biological systems is achieved by cooperatively recruiting multiple copies of regulatory biomolecules. Nevertheless, the multiplexing capability of artificial fluorescent amplifiers is limited due to the size limit and lack of modularity. Here, we develop Cayley tree-like fractal DNA frameworks to topologically encode the fluorescence states for multiplexed detection of low-abundance targets. Taking advantage of the self-similar topology of Cayley tree, we use only 16 DNA ...[more]