Ontology highlight
ABSTRACT:
SUBMITTER: Giuditta A
PROVIDER: S-EPMC7199793 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Giuditta Antonio A Casalino Joyce J
Frontiers in molecular neuroscience 20200428
Brain metabolic DNA (BMD) is continuously synthesized by reverse transcription in presynaptic synaptosomes and astroglia, and is partly transferred to nuclei after acquiring the double stranded configuration. Synthesis and turnover of BMD are markedly dependent on brain activity, as shown by circadian oscillations, environmental enrichment and impoverishment, and a variety of learning protocols. In rodents learning a two-way active avoidance task, BMD synthesis doubles, thus raising the possibil ...[more]