Ontology highlight
ABSTRACT:
SUBMITTER: Sabo Y
PROVIDER: S-EPMC7199802 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cell reports 20200301 12
IQGAP1 is a master regulator of many cellular processes, including intracellular vesicle trafficking and endocytosis. We show that depletion of IQGAP1 in a variety of cell types increases the release of HIV-1 infectious virions and that overexpression diminishes virion production, with neither affecting the early stages of infection. IQGAP1 negatively regulates the steady-state levels of HIV-1 Gag at the plasma membrane, the site of assembly. We establish that IQGAP1 interacts with both the nucl ...[more]