Ontology highlight
ABSTRACT:
SUBMITTER: Spriggs CC
PROVIDER: S-EPMC7199864 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
The Journal of cell biology 20200501 5
During entry, viruses must navigate through the host endomembrane system, penetrate cellular membranes, and undergo capsid disassembly to reach an intracellular destination that supports infection. How these events are coordinated is unclear. Here, we reveal an unexpected function of a cellular motor adaptor that coordinates virus membrane penetration and disassembly. Polyomavirus SV40 traffics to the endoplasmic reticulum (ER) and penetrates a virus-induced structure in the ER membrane called " ...[more]