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Density and morphology of coronary artery calcium for the prediction of cardiovascular events: insights from the Framingham Heart Study.


ABSTRACT: OBJECTIVES:To investigate the association between directly measured density and morphology of coronary artery calcium (CAC) with cardiovascular disease (CVD) events, using computed tomography (CT). METHODS:Framingham Heart Study (FHS) participants with CAC in noncontrast cardiac CT (2002-2005) were included and followed until 2016. Participants with known CVD or uninterpretable CT scans were excluded. We assessed and correlated (Spearman) CAC density, CAC volume, and the number of calcified segments. Moreover, we counted morphology features including shape (cylindrical, spherical, semi-tubular, and spotty), location (bifurcation, facing pericardium, or facing myocardium), and boundary regularity. In multivariate Cox regression analyses, we associated all CAC characteristics with CVD events (CVD-death, myocardial infarction, stroke). RESULTS:Among 1330 included participants (57.8?±?11.7 years; 63% male), 73 (5.5%) experienced CVD events in a median follow-up of 9.1 (7.8-10.1) years. CAC density correlated strongly with CAC volume (Spearman's ??=?0.75; p?

SUBMITTER: Foldyna B 

PROVIDER: S-EPMC7199920 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Density and morphology of coronary artery calcium for the prediction of cardiovascular events: insights from the Framingham Heart Study.

Foldyna Borek B   Eslami Parastou P   Scholtz Jan-Erik JE   Baltrusaitis Kristin K   Lu Michael T MT   Massaro Joseph M JM   D'Agostino Ralph B RB   Ferencik Maros M   Aerts Hugo J W L HJWL   O'Donnell Christopher J CJ   Hoffmann Udo U  

European radiology 20190502 11


<h4>Objectives</h4>To investigate the association between directly measured density and morphology of coronary artery calcium (CAC) with cardiovascular disease (CVD) events, using computed tomography (CT).<h4>Methods</h4>Framingham Heart Study (FHS) participants with CAC in noncontrast cardiac CT (2002-2005) were included and followed until 2016. Participants with known CVD or uninterpretable CT scans were excluded. We assessed and correlated (Spearman) CAC density, CAC volume, and the number of  ...[more]

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