Ontology highlight
ABSTRACT:
SUBMITTER: Hiu JJ
PROVIDER: S-EPMC7200639 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Hiu Jia Jin JJ Yap Michelle Khai Khun MKK
Biochemical Society transactions 20200401 2
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes found in the venoms from most snake species. These enzymes have been structurally and functionally characterised for their pharmacological activities. Both PLA2 and LAAO from different venoms demonstrate considerable cytotoxic effects on cancer cells via induction of apoptosis, cell cycle arrest and suppression of proliferation. These enzymes produce more pronounced cytotoxic effects in cancer cells than normal cel ...[more]