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Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia.

ABSTRACT: Mycobacterium tuberculosis (MTB) is commonly used as a model to study pathogenicity and multiple drug resistance in bacteria. These MTB characteristics are highly dependent on the evolution and phylogeography of the bacterium. In this paper, we describe 15 new genomes of multidrug-resistant MTB (MDRTB) from Malaysia. The assessments and annotations on the genome assemblies suggest that strain differences are due to lineages and horizontal gene transfer during the course of evolution. The genomes show mutations listed in current drug resistance databases and global MTB collections. This genome data will augment existing information available for comparative genomic studies to understand MTB drug resistance mechanisms and evolution.

SUBMITTER: Tan JL

PROVIDER: S-EPMC7200664 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia.

Tan Joon Liang JL Simbun Alfred A Chan Kok-Gan KG Ngeow Yun Fong YF

Scientific data 20200505 1

Mycobacterium tuberculosis (MTB) is commonly used as a model to study pathogenicity and multiple drug resistance in bacteria. These MTB characteristics are highly dependent on the evolution and phylogeography of the bacterium. In this paper, we describe 15 new genomes of multidrug-resistant MTB (MDRTB) from Malaysia. The assessments and annotations on the genome assemblies suggest that strain differences are due to lineages and horizontal gene transfer during the course of evolution. The genomes ...[more]

PMID: 32371951

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