Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC7200799 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Zhang Weiqi W Zhang Shu S Yan Pengze P Ren Jie J Song Moshi M Li Jingyi J Lei Jinghui J Pan Huize H Wang Si S Ma Xibo X Ma Shuai S Li Hongyu H Sun Fei F Wan Haifeng H Li Wei W Chan Piu P Zhou Qi Q Liu Guang-Hui GH Tang Fuchou F Qu Jing J
Nature communications 20200505 1
Our understanding of how aging affects the cellular and molecular components of the vasculature and contributes to cardiovascular diseases is still limited. Here we report a single-cell transcriptomic survey of aortas and coronary arteries in young and old cynomolgus monkeys. Our data define the molecular signatures of specialized arteries and identify eight markers discriminating aortic and coronary vasculatures. Gene network analyses characterize transcriptional landmarks that regulate vascula ...[more]