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PROMIS® Adult Health Profiles: Efficient Short-Form Measures of Seven Health Domains.

ABSTRACT: BACKGROUND:There is a need for valid self-report measures of core health-related quality of life (HRQoL) domains. OBJECTIVE:To derive brief, reliable and valid health profile measures from the Patient Reported Outcomes Measurement Information System® (PROMIS®) item banks. METHODS:Literature review, investigator consensus process, item response theory (IRT) analysis, and expert review of scaling results from multiple PROMIS data sets. We developed 3 profile measures ranging in length from 29 to 57 questions. These profiles assess important HRQoL domains with highly informative subsets of items from respective item banks and yield reliable information across mild-to-severe levels of HRQoL experiences. Each instrument assesses the domains of pain interference, fatigue, depression, anxiety, sleep disturbance, physical function, and social function using 4-, 6-, and 8-item short forms for each domain, and an average pain intensity domain score, using a 0-10 numeric rating scale. RESULTS:With few exceptions, all domain short forms within the profile measures were highly reliable across at least 3 standard deviation (30 T-score) units and were strongly correlated with the full bank scores. Construct validity with ratings of general health and quality of life was demonstrated. Information to inform statistical power for clinical and general population samples is also provided. CONCLUSIONS:Although these profile measures have been used widely, with summary scoring routines published, description of their development, reliability, and initial validity has not been published until this article. Further evaluation of these measures and clinical applications are encouraged.

SUBMITTER: Cella D

PROVIDER: S-EPMC7201383 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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PROMIS<sup>®</sup> Adult Health Profiles: Efficient Short-Form Measures of Seven Health Domains.

Cella David D Choi Seung W SW Condon David M DM Schalet Ben B Hays Ron D RD Rothrock Nan E NE Yount Susan S Cook Karon F KF Gershon Richard C RC Amtmann Dagmar D DeWalt Darren A DA Pilkonis Paul A PA Stone Arthur A AA Weinfurt Kevin K Reeve Bryce B BB

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20190501 5

<h4>Background</h4>There is a need for valid self-report measures of core health-related quality of life (HRQoL) domains.<h4>Objective</h4>To derive brief, reliable and valid health profile measures from the Patient Reported Outcomes Measurement Information System<sup>®</sup> (PROMIS<sup>®</sup>) item banks.<h4>Methods</h4>Literature review, investigator consensus process, item response theory (IRT) analysis, and expert review of scaling results from multiple PROMIS data sets. We developed 3 pro ...[more]

PMID: 31104731

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Project description:AimsHeart failure (HF) is a common and morbid condition impacting multiple health domains. We previously reported the development of the PROMIS®-Plus-HF (PROMIS+HF) profile measure, including universal and HF-specific items. To facilitate use, we developed shorter, PROMIS+HF profiles intended for research and clinical use.Methods and resultsCandidate items were selected based on psychometric properties and symptom range coverage. HF clinicians (n = 43) rated item importance and clinical actionability. Based on these results, we developed the PROMIS+HF-27 and PROMIS+HF-10 profiles with summary scores (0-100) for overall, physical, mental, and social health. In a cross-sectional sample (n = 600), we measured internal consistency reliability (Cronbach's alpha and Spearman-Brown), test-retest reliability (intraclass coefficient; n = 100), known-groups validity via New York Heart Association (NYHA) class, and convergent validity with Kansas City Cardiomyopathy Questionnaire (KCCQ) scores. In a longitudinal sample (n = 75), we evaluated responsiveness of baseline/follow-up scores by calculating mean differences and Cohen's d and comparing with paired t-tests. Internal consistency was good to excellent (α 0.82-0.94) for all PROMIS+HF-27 scores and acceptable to good (α/Spearman-Brown 0.60-0.85) for PROMIS+HF-10 scores. Test-retest intraclass coefficients were acceptable to excellent (0.75-0.97). Both profiles demonstrated known-groups validity for the overall and physical health summary scores based on NYHA class, and convergent validity for nearly all scores compared with KCCQ scores. In the longitudinal sample, we demonstrated responsiveness for PROMIS+HF-27 and PROMIS+HF-10 overall and physical summary scores. For the PROMIS+HF overall summary scores, a group-based increase of 7.6-8.3 points represented a small to medium change (Cohen's d = 0.40-0.42). For the PROMIS+HF physical summary scores, a group-based increase of 5.0-5.9 points represented a small to medium change (Cohen's d = 0.29-0.35).ConclusionsThe PROMIS+HF-27 and PROMIS+HF-10 profiles demonstrated good psychometric characteristics with evidence of responsiveness for overall and physical health. These new measures can facilitate patient-centred research and clinical care, such as improving care quality through symptom monitoring, facilitating shared decision-making, evaluating quality of care, assessing new interventions, and monitoring during the initiation and titration of guideline-directed medical therapy.

Dataset Information

PROMIS® Adult Health Profiles: Efficient Short-Form Measures of Seven Health Domains.

Publications

PROMIS<sup>®</sup> Adult Health Profiles: Efficient Short-Form Measures of Seven Health Domains.

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