Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model.

ABSTRACT:

Objectives

We evaluated the effect of the different carrier systems on early vascular response through histological analysis and scanning electron microscopy using a porcine model.

Background

Although Synergy™ and Promus PREMIER™ share an identical stent material and drug elution (everolimus), they use different drug carrier systems: biodegradable abluminal coating polymer or durable conformal coating polymer, respectively. However, data regarding the impact of the different coating systems on vessel healing are currently limited.

Methods

Twelve Synergy™ and Promus PREMIER™ were implanted in 12 swine. Histopathological analysis of the stented segments was performed on the 2^nd and 14^th days after implantation. Morphometric analysis of the inflamma

SUBMITTER: Mori M 

PROVIDER: S-EPMC7201493 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature