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CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead.

ABSTRACT: Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. Like other technologies, CAR-T cell therapy has undergone a long development process, and persistent explorations of the actions of the intracellular signaling domain and make several improvements have led to the superior efficacy when anti-CD19 CAR-T cell treatments in B cell cancers. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. This review mainly describes the toxicity of CAR-T cell therapy and the challenges of CAR-T cells in the treatment of solid tumors, and looks forward to future development and opportunities for immunotherapy and reviews major breakthroughs in CAR-T cell therapy.

SUBMITTER: Zhang Q

PROVIDER: S-EPMC7201836 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead.

Zhang Qingyang Q Ping Jieming J Huang Zirui Z Zhang Xiaoli X Zhou Jingyi J Wang Gangyang G Liu Shaoyang S Ma Jianjun J

Journal of immunology research 20200117

Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. Like other technologies, CAR-T cell therapy has undergone a long development process, and persistent explorations of the actions of the intracellular signaling domain and make several improvements have led to the superior efficacy when anti-CD19 CAR-T cell treatments in B cell cancers. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have be ...[more]

PMID: 32411789

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