Unknown

Dataset Information

0

CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead.


ABSTRACT: Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. Like other technologies, CAR-T cell therapy has undergone a long development process, and persistent explorations of the actions of the intracellular signaling domain and make several improvements have led to the superior efficacy when anti-CD19 CAR-T cell treatments in B cell cancers. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. This review mainly describes the toxicity of CAR-T cell therapy and the challenges of CAR-T cells in the treatment of solid tumors, and looks forward to future development and opportunities for immunotherapy and reviews major breakthroughs in CAR-T cell therapy.

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7201836 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead.

Zhang Qingyang Q   Ping Jieming J   Huang Zirui Z   Zhang Xiaoli X   Zhou Jingyi J   Wang Gangyang G   Liu Shaoyang S   Ma Jianjun J  

Journal of immunology research 20200117


Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. Like other technologies, CAR-T cell therapy has undergone a long development process, and persistent explorations of the actions of the intracellular signaling domain and make several improvements have led to the superior efficacy when anti-CD19 CAR-T cell treatments in B cell cancers. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have be  ...[more]

Similar Datasets

| S-EPMC4718736 | biostudies-literature
| S-EPMC8230324 | biostudies-literature
| S-EPMC6771592 | biostudies-literature
| S-EPMC4907357 | biostudies-literature
| S-EPMC3610617 | biostudies-other
| S-EPMC5718207 | biostudies-literature
| S-EPMC8172140 | biostudies-literature
| S-EPMC7058784 | biostudies-literature
| S-EPMC5491361 | biostudies-literature
| S-EPMC3510240 | biostudies-literature