Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica.

ABSTRACT: Ephedra sinica Stapf (EP) has a long medication history dating back centuries in the world. There were some reports of adverse effects in the central nervous system (CNS) resulting from administration of a drug containing EP or ephedrine. Compared with alkaloid monomer compounds, the effects of EP on the CNS are usually neglected. It is necessary to explore CNS affection which is helpful to use EP rationally. However, the affection and the changes of substances by EP in the brain are still unknown because the effects of drug on the brain also exhibit different tendency and distribution and usually lead to diversity of metabolite alteration in different regions. In this study, metabolomics based on different brain regions was used to investigate the affection mechanism of EP in the CNS. The

SUBMITTER: Liao Z 

PROVIDER: S-EPMC7201840 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature