Ontology highlight
ABSTRACT:
SUBMITTER: Francisco MA
PROVIDER: S-EPMC7201926 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Francisco Michelle A MA Wanggou Siyi S Fan Jerry J JJ Dong Weifan W Chen Xin X Momin Ali A Abeysundara Namal N Min Hyun-Kee HK Chan Jade J McAdam Rochelle R Sia Marian M Pusong Ronwell J RJ Liu Shixuan S Patel Nish N Ramaswamy Vijay V Kijima Noriyuki N Wang Lu-Yang LY Song Yuanquan Y Kafri Ran R Taylor Michael D MD Li Xuejun X Huang Xi X
The Journal of experimental medicine 20200501 5
Ion channels represent a large class of drug targets, but their role in brain cancer is underexplored. Here, we identify that chloride intracellular channel 1 (CLIC1) is overexpressed in human central nervous system malignancies, including medulloblastoma, a common pediatric brain cancer. While global knockout does not overtly affect mouse development, genetic deletion of CLIC1 suppresses medulloblastoma growth in xenograft and genetically engineered mouse models. Mechanistically, CLIC1 enriches ...[more]