Dataset Information

Expression of yhwaz and gene regulation network in hepatocellular carcinoma.

ABSTRACT: The adaptor protein 14-3-3? is encoded by the yhwaz gene and implicated in a wide range of biological processes. In tumorigenesis, 14-3-3? recognizes specific phosphorylation motifs and interacts with hundreds of target proteins and is, thus, involved in the regulation of tumor proliferation, migration and differentiation. In the present study, bioinformatics tools were used to analyze data from The Cancer Genome Atlas and Gene Expression Omnibus databases and the expression of yhwaz, and gene regulation networks were identified as potentially relevant in hepatocellular carcinoma (HCC). In HCC, yhwaz expression was demonstrated to be upregulated and significantly associated with poor prognosis. Expression levels of microRNAs targeting yhwaz were associated with improved prognosis in patients with liver cancer. Gene networks that are regulated by yhwaz were found to be involved in cell cycle regulation and tumorigenesis, indicating the potential use of the expression levels of yhwaz in liver tissue as predictive biomarkers in patients with liver cancer. In the present study, yhwaz was identified as a gene of interest through data mining gene expression databases and its involvement in regulatory networks in HCC was indicated. Therefore, further in vitro and in vivo studies on the role of yhwaz in the carcinogenesis of HCC would be greatly beneficial.

SUBMITTER: Lin Y

PROVIDER: S-EPMC7202284 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Expression of yhwaz and gene regulation network in hepatocellular carcinoma.

Lin Yi Y Sun Ling L Ye Xiaolei X

Oncology letters 20200327 6

The adaptor protein 14-3-3ζ is encoded by the yhwaz gene and implicated in a wide range of biological processes. In tumorigenesis, 14-3-3ζ recognizes specific phosphorylation motifs and interacts with hundreds of target proteins and is, thus, involved in the regulation of tumor proliferation, migration and differentiation. In the present study, bioinformatics tools were used to analyze data from The Cancer Genome Atlas and Gene Expression Omnibus databases and the expression of yhwaz, and gene r ...[more]

PMID: 32382342

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Project description:BackgroundHepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide, and the mechanisms that lead to the disease are still relatively unclear. However, with the development of high-throughput technologies it is possible to gain a systematic view of biological systems to enhance the understanding of the roles of genes associated with HCC. Thus, analysis of the mechanism of molecule interactions in the context of gene regulatory networks can reveal specific sub-networks that lead to the development of HCC.ResultsIn this study, we aimed to identify the most important gene regulations that are dysfunctional in HCC generation. Our method for constructing gene regulatory network is based on predicted target interactions, experimentally-supported interactions, and co-expression model. Regulators in the network included both transcription factors and microRNAs to provide a complete view of gene regulation. Analysis of gene regulatory network revealed that gene regulation in HCC is highly modular, in which different sets of regulators take charge of specific biological processes. We found that microRNAs mainly control biological functions related to mitochondria and oxidative reduction, while transcription factors control immune responses, extracellular activity and the cell cycle. On the higher level of gene regulation, there exists a core network that organizes regulations between different modules and maintains the robustness of the whole network. There is direct experimental evidence for most of the regulators in the core gene regulatory network relating to HCC. We infer it is the central controller of gene regulation. Finally, we explored the influence of the core gene regulatory network on biological pathways.ConclusionsOur analysis provides insights into the mechanism of transcriptional and post-transcriptional control in HCC. In particular, we highlight the importance of the core gene regulatory network; we propose that it is highly related to HCC and we believe further experimental validation is worthwhile.

Dataset Information

Expression of yhwaz and gene regulation network in hepatocellular carcinoma.

Publications

Expression of yhwaz and gene regulation network in hepatocellular carcinoma.

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