Ontology highlight
ABSTRACT:
SUBMITTER: Levasseur EM
PROVIDER: S-EPMC7202401 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Levasseur Esther M EM Yamada Kentaro K Piñeros Annie R AR Wu Wenting W Syed Farooq F Orr Kara S KS Anderson-Baucum Emily E Mastracci Teresa L TL Maier Bernhard B Mosley Amber L AL Liu Yunlong Y Bernal-Mizrachi Ernesto E Alonso Laura C LC Scott Donald D Garcia-Ocaña Adolfo A Tersey Sarah A SA Mirmira Raghavendra G RG
Science signaling 20191203 610
Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of <i>Dhps</i> is embryonically lethal, its role in normal postnatal cellular function in vivo remains unknown. We generated a mouse model that enabled the inducible, postnatal deletion of <i>Dhps</i> specifically in postnatal islet β cells, which function to maintain glucose ho ...[more]