Ontology highlight
ABSTRACT:
SUBMITTER: van Veen JE
PROVIDER: S-EPMC7202561 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
van Veen J Edward JE Kammel Laura G LG Bunda Patricia C PC Shum Michael M Reid Michelle S MS Massa Megan G MG Arneson Douglas D Park Jae W JW Zhang Zhi Z Joseph Alexia M AM Hrncir Haley H Liesa Marc M Arnold Arthur P AP Yang Xia X Correa Stephanie M SM
Nature metabolism 20200413 4
Estrogen receptor a (ERa) signaling in the ventromedial hypothalamus (VMH) contributes to energy homeostasis by modulating physical activity and thermogenesis. However, the precise neuronal populations involved remain undefined. Here, we describe six neuronal populations in the mouse VMH by using single-cell RNA transcriptomics and in situ hybridization. ERa is enriched in populations showing sex biased expression of reprimo (<i>Rprm</i>), tachykinin 1 (<i>Tac1</i>), and prodynorphin (<i>Pdyn</i ...[more]