Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC7202621 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wu Ying Y Broadaway K Alaine KA Raulerson Chelsea K CK Scott Laura J LJ Pan Calvin C Ko Arthur A He Aiqing A Tilford Charles C Fuchsberger Christian C Locke Adam E AE Stringham Heather M HM Jackson Anne U AU Narisu Narisu N Kuusisto Johanna J Pajukanta Päivi P Collins Francis S FS Boehnke Michael M Laakso Markku M Lusis Aldons J AJ Civelek Mete M Mohlke Karen L KL
Human molecular genetics 20191201 24
Integration of genome-wide association study (GWAS) signals with expression quantitative trait loci (eQTL) studies enables identification of candidate genes. However, evaluating whether nearby signals may share causal variants, termed colocalization, is affected by the presence of allelic heterogeneity, different variants at the same locus impacting the same phenotype. We previously identified eQTL in subcutaneous adipose tissue from 770 participants in the Metabolic Syndrome in Men (METSIM) stu ...[more]