Ontology highlight
ABSTRACT:
SUBMITTER: Pohl C
PROVIDER: S-EPMC7203126 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Pohl Carsten C Polli Fabiola F Schütze Tabea T Viggiano Annarita A Mózsik László L Jung Sascha S de Vries Maaike M Bovenberg Roel A L RAL Meyer Vera V Driessen Arnold J M AJM
Scientific reports 20200506 1
We present a Penicillium rubens strain with an industrial background in which the four highly expressed biosynthetic gene clusters (BGC) required to produce penicillin, roquefortine, chrysogine and fungisporin were removed. This resulted in a minimal secondary metabolite background. Amino acid pools under steady-state growth conditions showed reduced levels of methionine and increased intracellular aromatic amino acids. Expression profiling of remaining BGC core genes and untargeted mass spectro ...[more]