Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC7203577 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Li Wenguang W Lazarus Alan A Gao Hao H Martinez-Naharro Ana A Fontana Marianna M Hawkins Philip P Biswas Swethajit S Janiczek Robert R Cox Jennifer J Berry Colin C Husmeier Dirk D Luo Xiaoyu X
Frontiers in physiology 20200430
Deposition of amyloid in the heart can lead to cardiac dilation and impair its pumping ability. This ultimately leads to heart failure with worsening symptoms of breathlessness and fatigue due to the progressive loss of elasticity of the myocardium. Biomarkers linked to the clinical deterioration can be crucial in developing effective treatments. However, to date the progression of cardiac amyloidosis is poorly characterized. There is an urgent need to identify key predictors for disease progres ...[more]