Ontology highlight
ABSTRACT:
SUBMITTER: Martin K
PROVIDER: S-EPMC7203682 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Martin Kea K Junker Ursula U Tritto Elaine E Sutter Esther E Rubic-Schneider Tina T Morgan Hannah H Niwa Satoru S Li Jianping J Schlapbach Achim A Walker Dana D Bigaud Marc M Beerli Christian C Littlewood-Evans Amanda A Rudolph Bettina B Laisney Marc M Ledieu David D Beltz Karen K Quancard Jean J Bornancin Frédéric F Zamurovic Ribrioux Natasa N Calzascia Thomas T
Frontiers in immunology 20200430
Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell malignancies. Despite these protective effects, the severe reduction in regulatory T cells (Tregs) and the associated IPEX-like pathology occurring upon congenital disruption of the MALT1 protease in mice has raised concerns about the long-term safety of MALT1 inhibition. Here we describe the results of a series of toxicology studies in rat and dog s ...[more]