IL-6 and INF-? levels in patients with brucellosis in severe epidemic region, Xinjiang, China.

ABSTRACT: BACKGROUND:The incidence of brucellosis, which is caused by the Brucella species of bacteria, is rapidly rising worldwide; however, few studies have investigated the immune response to this pathogen and clinical biochemical features. In this paper, we examined the levels of various cytokines and inflammatory factors as well as clinical course characteristics in patients with brucellosis, in order to provide evidence for the diagnosis, assessment, and prognosis of this infectious disease. METHODS:A total of 191 brucellosis inpatients (50 acute cases and 141 chronic cases), as well as 60 healthy control subjects, were included in the analysis. We investigated changes in the levels of six cytokines (IL-4, IL-6, IL-10, IL-17, TNF-?, INF-?) and related clinical biochemical markers in patients with acute and chronic brucellosis in Xinjiang, China. Possible factors were statistically analyzed using the t test, ?2 test, z test and a multivariate logistic stepwise regression test. RESULTS:We found that IL-4, IL-6, IL-10, IL-17, IFN-?, and TNF-? levels were higher in those with brucellosis than in controls (P?

SUBMITTER: Lin ZQ 

PROVIDER: S-EPMC7203901 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature