Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto T
PROVIDER: S-EPMC7204404 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Matsumoto Tomonori T Wakefield Leslie L Tarlow Branden David BD Grompe Markus M
Cell stem cell 20191219 1
The identity of cellular populations that drive liver regeneration after injury is the subject of intense study, and the contributions of polyploid hepatocytes to organ regeneration and homeostasis have not been systematically assessed. Here, we developed a multicolor reporter allele system to genetically label and trace polyploid cells in situ. Multicolored polyploid hepatocytes undergo ploidy reduction and subsequent re-polyploidization after transplantation, providing direct evidence of the h ...[more]