Dataset Information

MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India.

ABSTRACT: Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. Here, we examined whether this association holds true in a different population, that is, 449 mainly male and adult malaria patients and 666 community controls in southwestern India. Plasmodium vivax malaria (67%) predominated over falciparum malaria (11%) and mixed species infections (22%). Overall, 59% of the study participants carried the miRNA-146a polymorphism. However, it was not associated with the odds of malaria, irrespective of parasite species. This underlines the importance of considering the complexities of clinical manifestations of malaria, genetic background, and parasite species when disentangling the role of human genetic variation, including those of miRNAs in malaria.

SUBMITTER: van Loon W

PROVIDER: S-EPMC7204598 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India.

van Loon Welmoed W Gai Prabhanjan P PP Kulkarni Suyamindra S SS Rasalkar Rashmi R Siegert Konrad K Wedam Jakob J Boloor Archith A Baliga Shantaram S Kumar Arun A Jain Animesh A Mahabala Chakrapani C Shenoy Damodara D Devi Rajeshwari R Gai Pramod P Mockenhaupt Frank P FP

The American journal of tropical medicine and hygiene 20200501 5

Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. Here, we examined whether this association holds true in a different population, that is, 449 mainly male and adult malaria patients and 666 community controls in southwestern India. <i>Plasmodium vivax</i> malaria (67%) predominated over falciparum malaria (11%) and mixed species infections (22%). Overall, 59% of the s ...[more]

PMID: 32124721

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Project description:BackgroundPlasmodium falciparum infection during pregnancy is a major cause of poor maternal health, adverse foetal outcome and infant mortality in sub-Saharan Africa. Genetic disposition is involved in susceptibility to malaria in pregnancy and its manifestation. MicroRNAs (miRNAs) influence gene regulation including that of innate immune responses. A miRNA-146a rs2910164 G > C single nucleotide polymorphism (SNP) has been associated with increased risks of several diseases, but no data as to malaria are available.MethodsThe association between miRNA-146a rs2910164 and P. falciparum infection among 509 Ghanaian women attending antenatal care (ANC) and 296 delivering Ghanaian primiparae was investigated. Malaria parasites were diagnosed by microscopy and PCR. Leukocyte-associated hemozoin in placental samples was recorded as well. Proportions were compared between groups by Fisher's exact test, and logistic regression models were used to adjust for possible confounders.ResultsBy PCR, P. falciparum infection was detected in 63% and 67% of ANC attendees and delivering primiparae, respectively. In both groups, two in three women were either heterozygous or homozygous for miRNA-146a rs2910164. Among ANC attendees, homozygosity conferred increased odds of infection (adjusted odds ratio (aOR), 2.3; 95% CI, 1.3-4.0), which was pronounced among primigravidae (aOR, 5.8; 95% CI, 1.6-26) but only marginal in multigravidae. Likewise, homozygosity for miRNA-146a rs2910164 in primiparae increased the odds of past or present placental P. falciparum infection almost six-fold (aOR, 5.9; 95% CI, 2.1-18).ConclusionsThese results indicate that SNP rs2910164 G > C is associated with increased odds for P. falciparum infection in first-time pregnant women who are considered to lack sufficient acquired immune responses against pregnancy-specific strains of P. falciparum. These findings suggest that miRNA-146a is involved in protective malarial immunity, and specifically in the innate component.

Dataset Information

MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India.

Publications

MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India.

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