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Exceptional Response to Everolimus in a Patient with Metastatic Castrate-Resistant Prostate Cancer Harboring a PTEN Inactivating Mutation.

ABSTRACT: Prostate cancer is among the most common types of cancer in men. Early detection and proper medical intervention is crucial to ensuring successful treatment. Here we describe a patient clinically presenting with castrate-resistant prostate carcinoma. Comprehensive genomic profiling identified a PTEN inactivating mutation in the patient's tumor. After being heavily pretreated, the patient showed stable disease on everolimus, a PI3K-Akt-mTOR pathway inhibitor.

SUBMITTER: Kmak JA

PROVIDER: S-EPMC7204854 | biostudies-literature | 2020 Jan-Apr

REPOSITORIES: biostudies-literature

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Exceptional Response to Everolimus in a Patient with Metastatic Castrate-Resistant Prostate Cancer Harboring a PTEN Inactivating Mutation.

Kmak Jamie A JA Agarwal Nikita N He Yuting Y Heilmann Andreas M AM Miller Vincent A VA Ross Jeffrey S JS Pal Sumanta Kumar SK Ali Siraj M SM Kilari Deepak D

Case reports in oncology 20200101 1

Prostate cancer is among the most common types of cancer in men. Early detection and proper medical intervention is crucial to ensuring successful treatment. Here we describe a patient clinically presenting with castrate-resistant prostate carcinoma. Comprehensive genomic profiling identified a PTEN inactivating mutation in the patient's tumor. After being heavily pretreated, the patient showed stable disease on everolimus, a PI3K-Akt-mTOR pathway inhibitor. ...[more]

PMID: 32399016

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