Ontology highlight
ABSTRACT:
SUBMITTER: Cheng W
PROVIDER: S-EPMC7205255 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Cheng Wenwen W Ndoka Ermelinda E Hutch Chelsea C Roelofs Karen K MacKinnon Andrew A Khoury Basma B Magrisso Jack J Kim Ki Suk KS Rhodes Christopher J CJ Olson David P DP Seeley Randy J RJ Sandoval Darleen D Myers Martin G MG
JCI insight 20200409 7
Leptin receptor-expressing (LepRb-expressing) neurons of the nucleus tractus solitarius (NTS; LepRbNTS neurons) receive gut signals that synergize with leptin action to suppress food intake. NTS neurons that express preproglucagon (Ppg) (and that produce the food intake-suppressing PPG cleavage product glucagon-like peptide-1 [GLP1]) represent a subpopulation of mouse LepRbNTS cells. Using Leprcre, Ppgcre, and Ppgfl mouse lines, along with Designer Receptors Exclusively Activated by Designer Dru ...[more]