Ontology highlight
ABSTRACT:
SUBMITTER: Iwanaga N
PROVIDER: S-EPMC7205435 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Iwanaga Naoki N Sandquist Ivy I Wanek Alanna A McCombs Janet J Song Kejing K Kolls Jay K JK
JCI insight 20200423 8
Infections due to carbapenem-resistant Klebsiella pneumoniae have emerged as a global threat due to its widespread antimicrobial resistance. Transplant recipients and patients with hematologic malignancies have high mortality rate, suggesting host factors in susceptibility. We developed a model of pulmonary infection using ST258 strain C4, KPC-2 clone, which are predominant K. pneumoniae carbapenemase-producing (KPC-producing) bacteria, and demonstrated that Rag2-/- Il2rg-/- mice - but not WT C5 ...[more]