Ontology highlight
ABSTRACT:
SUBMITTER: Cubizolle A
PROVIDER: S-EPMC7205824 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Cubizolle Aurélie A Cia David D Moine Espérance E Jacquemot Nathalie N Guillou Laurent L Rosell Mélissa M Angebault-Prouteau Claire C Lenaers Guy G Meunier Isabelle I Vercauteren Joseph J Durand Thierry T Crauste Céline C Brabet Philippe P
Journal of cellular and molecular medicine 20200325 9
All-trans-retinal (atRAL) is a highly reactive carbonyl specie, known for its reactivity on cellular phosphatidylethanolamine in photoreceptor. It is generated by photoisomerization of 11-cis-retinal chromophore linked to opsin by the Schiff's base reaction. In ABCA4-associated autosomal recessive Stargardt macular dystrophy, atRAL results in carbonyl and oxidative stress, which leads to bisretinoid A2E, accumulation in the retinal pigment epithelium (RPE). This A2E-accumulation presents as lipo ...[more]