Ontology highlight
ABSTRACT:
SUBMITTER: Peterson QP
PROVIDER: S-EPMC7205884 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Peterson Quinn P QP Veres Adrian A Chen Lihua L Slama Michael Q MQ Kenty Jennifer H R JHR Hassoun Shaimaa S Brown Matthew R MR Dou Haiqiang H Duffy Caden D CD Zhou Quan Q Matveyenko Aleksey V AV Tyrberg Björn B Sörhede-Winzell Maria M Rorsman Patrik P Melton Douglas A DA
Nature communications 20200507 1
The generation of pancreatic cell types from renewable cell sources holds promise for cell replacement therapies for diabetes. Although most effort has focused on generating pancreatic beta cells, considerable evidence indicates that glucagon secreting alpha cells are critically involved in disease progression and proper glucose control. Here we report on the generation of stem cell-derived human pancreatic alpha (SC-alpha) cells from pluripotent stem cells via a transient pre-alpha cell interme ...[more]