Ontology highlight
ABSTRACT:
SUBMITTER: Yuan M
PROVIDER: S-EPMC7205996 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Yuan Menglang M Zhang Xinsheng X Zhang Jingbo J Wang Keyong K Zhang Yu Y Shang Wei W Zhang Yinan Y Cui Jingyi J Shi Xiaomeng X Na Heya H Fang Deyu D Zuo Yunfei Y Ren Shuangyi S
Cell death and differentiation 20190619 1
DC-SIGN is previously focused on its physiologic and pathophysiologic roles in immune cells. Little is known about whether DC-SIGN is expressed in malignant epithelial cells and how DC-SIGN participates in tumor progression. Here we showed that DC-SIGN expression was increased in metastatic colorectal cancer (CRC) cell lines and patient tissues. The overall survival in CRC patients with positive DC-SIGN was remarkably reduced. Gain of DC-SIGN function facilitated the CRC metastases both in vitro ...[more]