Ontology highlight
ABSTRACT:
SUBMITTER: Patel S
PROVIDER: S-EPMC7206119 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Patel Snahel S Webster Joshua D JD Varfolomeev Eugene E Kwon Youngsu C YC Cheng Jason H JH Zhang Juan J Dugger Debra L DL Wickliffe Kate E KE Maltzman Allie A Sujatha-Bhaskar Swathi S Bir Kohli Pawan P Ramaswamy Sreema S Deshmukh Gauri G Liederer Bianca M BM Fong Rina R Hamilton Greg G Lupardus Patrick P Caplazi Patrick P Lee Wyne P WP van Lookeren Campagne Menno M Johnson Adam A McKenzie Brent S BS Junttila Melissa R MR Newton Kim K Vucic Domagoj D
Cell death and differentiation 20190517 1
The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity has been implicated in a range of inflammatory, neurodegenerative, and oncogenic diseases. Here, we explore the effect of inhibiting RIP1 genetically, using knock-in mice that express catalytically inactive RIP1 D138N, or pharmacologically, using the murine-potent inhibitor GNE684. Inhibition of RIP1 reduced collagen antibody-induced arthri ...[more]