Ontology highlight
ABSTRACT:
SUBMITTER: Mishra PS
PROVIDER: S-EPMC7206749 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Mishra Pooja Shree PS Boutej Hejer H Soucy Geneviève G Bareil Christine C Kumar Sunny S Picher-Martel Vincent V Dupré Nicolas N Kriz Jasna J Julien Jean-Pierre JP
Acta neuropathologica communications 20200507 1
To test the hypothesis that the cerebrospinal fluid (CSF) could provide a spreading route for pathogenesis of amyotrophic lateral sclerosis (ALS), we have examined the effects of intraventricular infusion during 2 weeks of pooled CSF samples from sporadic ALS patients or control CSF samples into transgenic mice expressing human TDP43<sup>WT</sup> which do not develop pathological phenotypes. Infusion of ALS-CSF, but not of control CSF, triggered motor and cognitive dysfunction, as well as ALS-li ...[more]