Ontology highlight
ABSTRACT:
SUBMITTER: Choi JH
PROVIDER: S-EPMC7206793 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Choi Jin Huk JH Zhong Xue X McAlpine William W Liao Tzu-Chieh TC Zhang Duanwu D Fang Beibei B Russell Jamie J Ludwig Sara S Nair-Gill Evan E Zhang Zhao Z Wang Kuan-Wen KW Misawa Takuma T Zhan Xiaoming X Choi Mihwa M Wang Tao T Li Xiaohong X Tang Miao M Sun Qihua Q Yu Liyang L Murray Anne R AR Moresco Eva Marie Y EMY Beutler Bruce B
Science (New York, N.Y.) 20190501 6440
Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an <i>N</i>-ethyl-<i>N</i>-nitrosourea-induced mutation in the limb region 1-like gene (<i>Lmbr1l</i>), which encodes a membrane-spanning protein with no previously described function in immunity. The interaction of LMBR1L with glycoprotein 78 (GP78) and ubiquitin-associated domain-containing protein 2 (UBAC2) atten ...[more]